The Continental GP 4000 S II 700C Road Tire is the best road tire available. It has superb grip, rolling resistance, and puncture resistance. It is also very light. It does everything great and does not sacrifice one attribute (grip, weight, etc.) for another.
Commuting daily on some of the worst urban roads I've come across I've suddenly stopped stressing about what's ahead and now enjoy my rides. It's true they are more difficult to put on and they're heavier than my previous tires, but so far they've made my ride so much more enjoyable I don't care. So far no more changing changing flats at night, in the rain, at temperatures below freezing!